/* Страница применения дазатиниба - стили */

/* Hero секция */
.application-hero {
    background: linear-gradient(135deg, #2c3e50 0%, #34495e 50%, #3498db 100%);
    color: white;
    padding: 100px 0;
    text-align: center;
    position: relative;
    overflow: hidden;
}

.application-hero::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: url('data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 1000 1000"><defs><pattern id="grid" width="50" height="50" patternUnits="userSpaceOnUse"><path d="M 50 0 L 0 0 0 50" fill="none" stroke="rgba(255,255,255,0.1)" stroke-width="1"/></pattern></defs><rect width="100%" height="100%" fill="url(%23grid)"/></svg>');
    opacity: 0.3;
}

.hero-content {
    position: relative;
    z-index: 2;
}

.hero-title {
    font-size: 3rem;
    font-weight: 700;
    margin-bottom: 1.5rem;
    text-shadow: 2px 2px 4px rgba(0, 0, 0, 0.3);
}

.hero-subtitle {
    font-size: 1.3rem;
    margin-bottom: 3rem;
    opacity: 0.9;
    max-width: 800px;
    margin-left: auto;
    margin-right: auto;
    line-height: 1.6;
}

.hero-stats {
    display: flex;
    justify-content: center;
    gap: 3rem;
    flex-wrap: wrap;
}

.stat-item {
    background: rgba(255, 255, 255, 0.15);
    backdrop-filter: blur(10px);
    padding: 2rem;
    border-radius: 20px;
    border: 1px solid rgba(255, 255, 255, 0.2);
    min-width: 180px;
    transition: transform 0.3s ease;
}

.stat-item:hover {
    transform: translateY(-5px);
}

.stat-number {
    font-size: 2.5rem;
    font-weight: 700;
    margin-bottom: 0.5rem;
    color: #f39c12;
}

.stat-label {
    font-size: 0.95rem;
    opacity: 0.9;
    line-height: 1.4;
}

/* Обзор применения */
.application-overview {
    padding: 80px 0;
}

.application-overview h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.overview-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(350px, 1fr));
    gap: 2rem;
}

.overview-card {
    background: white;
    padding: 2.5rem;
    border-radius: 20px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    transition: transform 0.3s ease, box-shadow 0.3s ease;
    border-left: 5px solid transparent;
}

.overview-card:hover {
    transform: translateY(-5px);
    box-shadow: 0 20px 40px rgba(0, 0, 0, 0.15);
}

.overview-card.primary {
    border-left-color: #e74c3c;
}

.overview-card.secondary {
    border-left-color: #3498db;
}

.overview-card.tertiary {
    border-left-color: #27ae60;
}

.card-icon {
    font-size: 3rem;
    margin-bottom: 1.5rem;
}

.overview-card h3 {
    font-size: 1.5rem;
    color: #2c3e50;
    margin-bottom: 1rem;
}

.overview-card p {
    color: #555;
    line-height: 1.6;
    margin-bottom: 1.5rem;
}

.feature-list,
.pharma-list {
    list-style: none;
    padding: 0;
}

.feature-list li,
.pharma-list li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.feature-list li::before {
    content: "✓";
    color: #27ae60;
    font-weight: bold;
    position: absolute;
    left: 0;
}

.pharma-list li::before {
    content: "●";
    color: #3498db;
    position: absolute;
    left: 0;
}

/* Данные эффективности */
.efficacy-data {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.efficacy-item {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 1rem;
    background: #f8f9fa;
    border-radius: 10px;
    border-left: 4px solid #3498db;
}

.efficacy-label {
    color: #555;
    font-size: 0.95rem;
}

.efficacy-value {
    font-weight: 700;
    font-size: 1.25rem;
    color: #27ae60;
}

/* Протоколы лечения */
.treatment-protocols {
    padding: 80px 0;
}

.treatment-protocols h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.protocols-tabs {
    max-width: 1200px;
    margin: 0 auto;
}

.protocol-nav {
    display: flex;
    gap: 1rem;
    margin-bottom: 3rem;
    overflow-x: auto;
    padding-bottom: 1rem;
}

.protocol-tab {
    background: #f8f9fa;
    border: none;
    padding: 1rem 2rem;
    border-radius: 25px;
    font-weight: 600;
    color: #555;
    cursor: pointer;
    transition: all 0.3s ease;
    white-space: nowrap;
    min-width: 200px;
}

.protocol-tab:hover {
    background: #e9ecef;
    color: #333;
}

.protocol-tab.active {
    background: linear-gradient(135deg, #3498db, #2980b9);
    color: white;
    box-shadow: 0 4px 15px rgba(52, 152, 219, 0.3);
}

.protocol-content {
    display: none;
    background: white;
    padding: 3rem;
    border-radius: 20px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
}

.protocol-content.active {
    display: block;
}

.protocol-content h3 {
    color: #2c3e50;
    font-size: 2rem;
    margin-bottom: 2rem;
    text-align: center;
}

/* Информация о дозировке */
.dosage-info {
    margin-bottom: 3rem;
}

.dose-card {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
    padding: 2rem;
    border-radius: 15px;
    text-align: center;
}

.dose-card h4 {
    margin-bottom: 1.5rem;
    font-size: 1.3rem;
}

.dose-details {
    display: flex;
    justify-content: center;
    align-items: center;
    gap: 2rem;
    flex-wrap: wrap;
}

.dose-amount {
    font-size: 3rem;
    font-weight: 700;
    color: #f39c12;
}

.dose-frequency {
    font-size: 1.25rem;
    opacity: 0.9;
}

.dose-timing,
.dose-alternative,
.dose-note,
.dose-duration {
    font-size: 0.95rem;
    opacity: 0.8;
}

/* Цели лечения */
.treatment-goals {
    margin-bottom: 3rem;
}

.treatment-goals h4 {
    color: #2c3e50;
    font-size: 1.5rem;
    margin-bottom: 2rem;
}

.goals-timeline {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: 1.5rem;
}

.goal-milestone {
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 15px;
    text-align: center;
    border-left: 4px solid #3498db;
    transition: transform 0.3s ease;
}

.goal-milestone:hover {
    transform: translateY(-3px);
}

.milestone-time {
    background: #3498db;
    color: white;
    padding: 0.5rem 1rem;
    border-radius: 20px;
    font-weight: 600;
    margin-bottom: 1rem;
    display: inline-block;
}

.milestone-target {
    color: #555;
    line-height: 1.5;
}

/* Оценка ответа */
.response-assessment {
    margin-bottom: 3rem;
}

.response-assessment h4 {
    color: #2c3e50;
    font-size: 1.5rem;
    margin-bottom: 2rem;
}

.response-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 2rem;
}

.response-card {
    padding: 2rem;
    border-radius: 15px;
    border-left: 5px solid;
}

.response-card.optimal {
    background: #d4edda;
    border-left-color: #27ae60;
}

.response-card.warning {
    background: #fff3cd;
    border-left-color: #f39c12;
}

.response-card.failure {
    background: #f8d7da;
    border-left-color: #e74c3c;
}

.response-card h5 {
    margin-bottom: 1rem;
    font-size: 1.2rem;
}

.response-card.optimal h5 {
    color: #155724;
}

.response-card.warning h5 {
    color: #856404;
}

.response-card.failure h5 {
    color: #721c24;
}

.response-card ul {
    list-style: none;
    padding: 0;
    margin-bottom: 1.5rem;
}

.response-card li {
    padding: 0.5rem 0;
    position: relative;
    padding-left: 1.5rem;
}

.response-card.optimal li::before {
    content: "✓";
    color: #27ae60;
    font-weight: bold;
    position: absolute;
    left: 0;
}

.response-card.warning li::before {
    content: "⚠️";
    position: absolute;
    left: 0;
}

.response-card.failure li::before {
    content: "✗";
    color: #e74c3c;
    font-weight: bold;
    position: absolute;
    left: 0;
}

.response-action {
    font-weight: 600;
    padding: 0.75rem 1rem;
    border-radius: 8px;
    text-align: center;
}

.response-card.optimal .response-action {
    background: #27ae60;
    color: white;
}

.response-card.warning .response-action {
    background: #f39c12;
    color: white;
}

.response-card.failure .response-action {
    background: #e74c3c;
    color: white;
}

/* Критерии фазы акселерации */
.accelerated-criteria {
    margin-bottom: 3rem;
}

.accelerated-criteria h4 {
    color: #2c3e50;
    font-size: 1.5rem;
    margin-bottom: 2rem;
}

.criteria-list {
    background: #f8f9fa;
    padding: 2rem;
    border-radius: 15px;
    border-left: 5px solid #f39c12;
}

.criteria-item {
    display: flex;
    align-items: flex-start;
    gap: 1rem;
    padding: 0.75rem 0;
    border-bottom: 1px solid #e9ecef;
}

.criteria-item:last-child {
    border-bottom: none;
}

.criteria-marker {
    color: #f39c12;
    font-weight: bold;
    margin-top: 0.25rem;
}

/* Подход к лечению */
.treatment-approach,
.treatment-strategy {
    margin-bottom: 3rem;
}

.treatment-approach h4,
.treatment-strategy h4 {
    color: #2c3e50;
    font-size: 1.5rem;
    margin-bottom: 2rem;
}

.approach-steps {
    display: flex;
    gap: 2rem;
    flex-wrap: wrap;
}

.step-item {
    flex: 1;
    min-width: 250px;
    display: flex;
    align-items: flex-start;
    gap: 1rem;
}

.step-number {
    width: 40px;
    height: 40px;
    background: linear-gradient(135deg, #3498db, #2980b9);
    color: white;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: 700;
    flex-shrink: 0;
}

.step-content h5 {
    color: #2c3e50;
    margin-bottom: 0.5rem;
}

.step-content p {
    color: #555;
    line-height: 1.5;
}

/* Типы бластного криза */
.blast-crisis-types {
    margin-bottom: 3rem;
}

.blast-crisis-types h4 {
    color: #2c3e50;
    font-size: 1.5rem;
    margin-bottom: 2rem;
}

.crisis-types-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 2rem;
}

.crisis-type {
    padding: 2rem;
    border-radius: 15px;
    border-left: 5px solid;
}

.crisis-type.myeloid {
    background: #ffeaa7;
    border-left-color: #f39c12;
}

.crisis-type.lymphoid {
    background: #ddd6fe;
    border-left-color: #8b5cf6;
}

.crisis-type h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.crisis-type ul {
    list-style: none;
    padding: 0;
}

.crisis-type li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.crisis-type li::before {
    content: "•";
    color: #2c3e50;
    font-weight: bold;
    position: absolute;
    left: 0;
}

/* Фазы стратегии лечения */
.strategy-phases {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.phase-card {
    background: #f8f9fa;
    padding: 2rem;
    border-radius: 15px;
    border-left: 5px solid #3498db;
}

.phase-card h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.2rem;
}

.phase-card p {
    color: #555;
    line-height: 1.6;
}

/* Ph+ ОЛЛ фазы */
.all-phases {
    margin-bottom: 3rem;
}

.all-phases h4 {
    color: #2c3e50;
    font-size: 1.5rem;
    margin-bottom: 2rem;
}

.phase-section {
    margin-bottom: 3rem;
    background: #f8f9fa;
    padding: 2rem;
    border-radius: 15px;
    border-left: 5px solid #8b5cf6;
}

.phase-section h5 {
    color: #2c3e50;
    font-size: 1.3rem;
    margin-bottom: 1.5rem;
}

.phase-details {
    display: grid;
    grid-template-columns: 1fr 2fr;
    gap: 2rem;
    align-items: start;
}

.phase-section h6 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.combination-therapy ul {
    list-style: none;
    padding: 0;
}

.combination-therapy li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.combination-therapy li::before {
    content: "●";
    color: #8b5cf6;
    position: absolute;
    left: 0;
}

.expected-results,
.maintenance-details {
    background: white;
    padding: 1.5rem;
    border-radius: 10px;
}

.results-stats {
    display: flex;
    gap: 2rem;
    justify-content: center;
    margin-top: 1rem;
}

.result-stat {
    text-align: center;
}

.stat-value {
    display: block;
    font-size: 1.5rem;
    font-weight: 700;
    color: #27ae60;
}

.stat-label {
    font-size: 0.9rem;
    color: #555;
}

/* Трансплантация */
.transplant-considerations {
    margin-bottom: 3rem;
}

.transplant-considerations h4 {
    color: #2c3e50;
    font-size: 1.5rem;
    margin-bottom: 2rem;
}

.transplant-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 2rem;
}

.transplant-card {
    background: #e8f4fd;
    padding: 2rem;
    border-radius: 15px;
    border-left: 5px solid #3498db;
}

.transplant-card h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.transplant-card ul {
    list-style: none;
    padding: 0;
}

.transplant-card li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.transplant-card li::before {
    content: "✓";
    color: #3498db;
    font-weight: bold;
    position: absolute;
    left: 0;
}

/* Мониторинг */
.monitoring-section {
    padding: 80px 0;
}

.monitoring-section h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.monitoring-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(350px, 1fr));
    gap: 2rem;
}

.monitoring-card {
    background: white;
    padding: 2rem;
    border-radius: 20px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    transition: transform 0.3s ease;
}

.monitoring-card:hover {
    transform: translateY(-5px);
}

.monitoring-card h3 {
    color: #2c3e50;
    margin-bottom: 1.5rem;
    font-size: 1.3rem;
}

.monitoring-timeline {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.timeline-item {
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #3498db;
}

.timeline-period {
    font-weight: 600;
    color: #2c3e50;
    margin-bottom: 0.5rem;
}

.timeline-frequency {
    background: #3498db;
    color: white;
    padding: 0.25rem 0.75rem;
    border-radius: 15px;
    font-size: 0.85rem;
    display: inline-block;
    margin-bottom: 1rem;
}

.timeline-tests ul {
    list-style: none;
    padding: 0;
    margin: 0;
}

.timeline-tests li {
    padding: 0.25rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.timeline-tests li::before {
    content: "🔬";
    position: absolute;
    left: 0;
}

/* Управление побочными эффектами */
.side-effects-management {
    padding: 80px 0;
}

.side-effects-management h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.side-effects-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(400px, 1fr));
    gap: 2rem;
}

.side-effect-card {
    background: white;
    border-radius: 20px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    overflow: hidden;
    transition: transform 0.3s ease;
}

.side-effect-card:hover {
    transform: translateY(-5px);
}

.side-effect-card h3 {
    background: linear-gradient(135deg, #e74c3c, #c0392b);
    color: white;
    padding: 1.5rem;
    margin: 0;
    font-size: 1.3rem;
}

.effect-info {
    padding: 2rem;
}

.effect-frequency {
    background: #f39c12;
    color: white;
    padding: 0.5rem 1rem;
    border-radius: 20px;
    font-size: 0.9rem;
    font-weight: 600;
    display: inline-block;
    margin-bottom: 1.5rem;
}

.effect-management h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.management-steps {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.management-step {
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #e74c3c;
}

.step-severity {
    background: #e74c3c;
    color: white;
    padding: 0.25rem 0.75rem;
    border-radius: 15px;
    font-size: 0.85rem;
    font-weight: 600;
    display: inline-block;
    margin-bottom: 1rem;
}

.step-actions p {
    font-weight: 600;
    margin-bottom: 0.75rem;
    color: #2c3e50;
}

.step-actions ul {
    list-style: none;
    padding: 0;
}

.step-actions li {
    padding: 0.25rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.step-actions li::before {
    content: "•";
    color: #e74c3c;
    font-weight: bold;
    position: absolute;
    left: 0;
}

/* Цитопения */
.cytopenia-management {
    display: flex;
    flex-direction: column;
    gap: 2rem;
}

.cytopenia-type {
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #3498db;
}

.cytopenia-type h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.management-algorithm {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.algorithm-step {
    display: flex;
    align-items: center;
    gap: 1rem;
    padding: 0.75rem;
    background: white;
    border-radius: 8px;
}

.threshold {
    background: #3498db;
    color: white;
    padding: 0.25rem 0.75rem;
    border-radius: 15px;
    font-size: 0.85rem;
    font-weight: 600;
    min-width: 120px;
    text-align: center;
}

.action {
    color: #555;
    font-size: 0.95rem;
}

/* Кардиотоксичность */
.cardiac-management {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.cardiac-type {
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #e74c3c;
}

.cardiac-type h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.cardiac-actions p {
    margin-bottom: 0.5rem;
    color: #555;
    line-height: 1.5;
}

/* ЖКТ нарушения */
.gi-management {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.gi-symptom {
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #f39c12;
}

.gi-symptom h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.symptom-treatment p {
    font-weight: 600;
    margin-bottom: 0.75rem;
    color: #2c3e50;
}

.symptom-treatment ul {
    list-style: none;
    padding: 0;
    margin-bottom: 1rem;
}

.symptom-treatment li {
    padding: 0.25rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.symptom-treatment li::before {
    content: "•";
    color: #f39c12;
    font-weight: bold;
    position: absolute;
    left: 0;
}

/* Особые клинические ситуации */
.special-situations {
    padding: 80px 0;
}

.special-situations h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.situations-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(400px, 1fr));
    gap: 2rem;
}

.situation-card {
    background: white;
    border-radius: 20px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    overflow: hidden;
    transition: transform 0.3s ease;
}

.situation-card:hover {
    transform: translateY(-5px);
}

.situation-card h3 {
    background: linear-gradient(135deg, #8b5cf6, #7c3aed);
    color: white;
    padding: 1.5rem;
    margin: 0;
    font-size: 1.3rem;
}

.situation-content {
    padding: 2rem;
}

.situation-content h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.situation-content h5 {
    color: #2c3e50;
    margin: 1rem 0 0.5rem 0;
}

.situation-content p {
    color: #555;
    line-height: 1.6;
    margin-bottom: 1rem;
}

.situation-content ul {
    list-style: none;
    padding: 0;
}

.situation-content li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.situation-content li::before {
    content: "•";
    color: #8b5cf6;
    font-weight: bold;
    position: absolute;
    left: 0;
}

/* Беременность */
.pregnancy-details {
    background: #fff3cd;
    padding: 1.5rem;
    border-radius: 10px;
    border: 2px solid #f39c12;
    margin-bottom: 1.5rem;
}

.planning-steps {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.planning-phase {
    background: #e8f4fd;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #3498db;
}

.planning-phase h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.fertility-info,
.lactation-info {
    margin-top: 1.5rem;
}

.lactation-info {
    background: #f8d7da;
    padding: 1.5rem;
    border-radius: 10px;
    border: 2px solid #e74c3c;
}

/* Пожилые пациенты */
.elderly-modifications {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.modification-section {
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #f39c12;
}

.modification-section h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

/* Смена терапии */
.switch-reasons {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 2rem;
    margin-bottom: 2rem;
}

.reason-category {
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #e74c3c;
}

.reason-category h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.switch-algorithm {
    margin-top: 2rem;
}

.switch-algorithm h4 {
    color: #2c3e50;
    margin-bottom: 1.5rem;
}

.algorithm-flow {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: 1.5rem;
}

.flow-step {
    display: flex;
    align-items: flex-start;
    gap: 1rem;
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #3498db;
}

.flow-step .step-number {
    width: 30px;
    height: 30px;
    background: linear-gradient(135deg, #3498db, #2980b9);
    color: white;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: 700;
    flex-shrink: 0;
    font-size: 0.9rem;
}

.flow-step .step-content h5 {
    color: #2c3e50;
    margin-bottom: 0.5rem;
    font-size: 1rem;
}

.flow-step .step-content p {
    color: #555;
    font-size: 0.9rem;
    line-height: 1.4;
}

/* TFR */
.tfr-criteria {
    margin-bottom: 2rem;
}

.tfr-criteria h5 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.criteria-checklist {
    background: #d4edda;
    padding: 1.5rem;
    border-radius: 10px;
    border: 2px solid #27ae60;
}

.criteria-item {
    display: flex;
    align-items: center;
    gap: 1rem;
    padding: 0.5rem 0;
}

.criteria-check {
    color: #27ae60;
    font-weight: bold;
    font-size: 1.2rem;
}

.tfr-monitoring {
    margin-bottom: 2rem;
}

.tfr-monitoring h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.monitoring-schedule {
    display: flex;
    gap: 1.5rem;
    flex-wrap: wrap;
}

.schedule-period {
    background: #e8f4fd;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #3498db;
    flex: 1;
    min-width: 200px;
}

.schedule-period h5 {
    color: #2c3e50;
    margin-bottom: 0.5rem;
}

.schedule-period p {
    color: #555;
    font-weight: 600;
}

.relapse-criteria {
    background: #f8d7da;
    padding: 1.5rem;
    border-radius: 10px;
    border: 2px solid #e74c3c;
}

.relapse-criteria h4 {
    color: #721c24;
    margin-bottom: 1rem;
}

.relapse-criteria ul {
    list-style: none;
    padding: 0;
}

.relapse-criteria li {
    padding: 0.5rem 0;
    color: #721c24;
    position: relative;
    padding-left: 1.5rem;
}

.relapse-criteria li::before {
    content: "⚠️";
    position: absolute;
    left: 0;
}

/* Практические рекомендации */
.practical-recommendations {
    padding: 80px 0;
}

.practical-recommendations h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.recommendations-sections {
    display: flex;
    flex-direction: column;
    gap: 3rem;
}

.recommendation-section {
    background: white;
    padding: 2.5rem;
    border-radius: 20px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
}

.recommendation-section h3 {
    color: #2c3e50;
    font-size: 1.8rem;
    margin-bottom: 2rem;
    text-align: center;
}

.tips-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 2rem;
}

.tip-category {
    background: #f8f9fa;
    padding: 2rem;
    border-radius: 15px;
    border-left: 5px solid #3498db;
}

.tip-category h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.2rem;
}

.tip-category ul {
    list-style: none;
    padding: 0;
}

.tip-category li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
    line-height: 1.5;
}

.tip-category li::before {
    content: "✓";
    color: #27ae60;
    font-weight: bold;
    position: absolute;
    left: 0;
}

/* Документация */
.documentation-requirements {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(350px, 1fr));
    gap: 2rem;
}

.doc-category {
    background: #f8f9fa;
    padding: 2rem;
    border-radius: 15px;
    border-left: 5px solid #8b5cf6;
}

.doc-category h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.2rem;
}

.doc-category ul {
    list-style: none;
    padding: 0;
}

.doc-category li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
    line-height: 1.5;
}

.doc-category li::before {
    content: "📋";
    position: absolute;
    left: 0;
}

/* Междисциплинарное сотрудничество */
.specialist-consultations {
    display: flex;
    flex-direction: column;
    gap: 2rem;
}

.consultation-group {
    background: #f8f9fa;
    padding: 2rem;
    border-radius: 15px;
    border-left: 5px solid #e74c3c;
}

.consultation-group h4 {
    color: #2c3e50;
    margin-bottom: 1.5rem;
    font-size: 1.2rem;
}

.specialist-list {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 1.5rem;
}

.specialist-item {
    background: white;
    padding: 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #3498db;
}

.specialist-item h5 {
    color: #2c3e50;
    margin-bottom: 0.75rem;
    font-size: 1.1rem;
}

.specialist-item p {
    color: #555;
    font-size: 0.95rem;
    line-height: 1.5;
    margin: 0;
}

/* Поддержка и контакты */
.support-contacts {
    padding: 80px 0;
}

.support-contacts h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.contacts-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(400px, 1fr));
    gap: 2rem;
}

.contact-card {
    background: white;
    padding: 2.5rem;
    border-radius: 20px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    border-left: 5px solid #3498db;
    transition: transform 0.3s ease;
}

.contact-card:hover {
    transform: translateY(-5px);
}

.contact-card h3 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.4rem;
}

.contact-card p {
    color: #555;
    line-height: 1.6;
    margin-bottom: 1.5rem;
}

.contact-details {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
    margin-bottom: 1.5rem;
}

.contact-item {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    color: #555;
}

.contact-item strong {
    color: #2c3e50;
    min-width: 120px;
}

.resources-links {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.resource-link {
    color: #3498db;
    text-decoration: none;
    font-weight: 500;
    padding: 0.75rem;
    background: #f8f9fa;
    border-radius: 8px;
    transition: all 0.3s ease;
    border-left: 4px solid #3498db;
}

.resource-link:hover {
    background: #e9ecef;
    color: #2980b9;
    transform: translateX(5px);
}

/* Медицинский дисклеймер */
.medical-disclaimer {
    padding: 60px 0;
}

.disclaimer-card {
    background: linear-gradient(135deg, #fff3cd, #ffeaa7);
    border: 2px solid #f39c12;
    border-radius: 20px;
    padding: 2.5rem;
    max-width: 900px;
    margin: 0 auto;
    text-align: center;
}

.disclaimer-card h3 {
    color: #d68910;
    font-size: 1.8rem;
    margin-bottom: 1.5rem;
}

.disclaimer-content p {
    color: #5d4e37;
    font-size: 1.1rem;
    line-height: 1.6;
    margin-bottom: 1.5rem;
}

.disclaimer-content ul {
    list-style: none;
    padding: 0;
    text-align: left;
    max-width: 600px;
    margin: 0 auto;
}

.disclaimer-content li {
    padding: 0.75rem 0;
    color: #5d4e37;
    position: relative;
    padding-left: 2rem;
    line-height: 1.5;
}

.disclaimer-content li::before {
    content: "⚠️";
    position: absolute;
    left: 0;
}

/* Адаптивный дизайн */
@media (max-width: 1024px) {
    .overview-grid {
        grid-template-columns: 1fr;
    }
    
    .monitoring-grid {
        grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    }
    
    .situations-grid {
        grid-template-columns: 1fr;
    }
    
    .phase-details {
        grid-template-columns: 1fr;
        gap: 1.5rem;
    }
    
    .results-stats {
        flex-direction: column;
        gap: 1rem;
    }
}

@media (max-width: 768px) {
    .hero-title {
        font-size: 2.2rem;
    }
    
    .hero-subtitle {
        font-size: 1.1rem;
    }
    
    .hero-stats {
        flex-direction: column;
        align-items: center;
        gap: 1.5rem;
    }
    
    .stat-item {
        min-width: 200px;
    }
    
    .protocol-nav {
        flex-direction: column;
        gap: 0.75rem;
    }
    
    .protocol-tab {
        min-width: auto;
        width: 100%;
    }
    
    .protocol-content {
        padding: 2rem 1.5rem;
    }
    
    .goals-timeline {
        grid-template-columns: 1fr;
    }
    
    .response-grid {
        grid-template-columns: 1fr;
    }
    
    .crisis-types-grid {
        grid-template-columns: 1fr;
    }
    
    .transplant-grid {
        grid-template-columns: 1fr;
    }
    
    .monitoring-grid {
        grid-template-columns: 1fr;
    }
    
    .side-effects-grid {
        grid-template-columns: 1fr;
    }
    
    .approach-steps {
        flex-direction: column;
    }
    
    .algorithm-flow {
        grid-template-columns: 1fr;
    }
    
    .monitoring-schedule {
        flex-direction: column;
    }
    
    .tips-grid {
        grid-template-columns: 1fr;
    }
    
    .documentation-requirements {
        grid-template-columns: 1fr;
    }
    
    .specialist-list {
        grid-template-columns: 1fr;
    }
    
    .contacts-grid {
        grid-template-columns: 1fr;
    }
    
    .dose-details {
        flex-direction: column;
        gap: 1rem;
    }
    
    .dose-amount {
        font-size: 2.5rem;
    }
    
    .switch-reasons {
        grid-template-columns: 1fr;
    }
}

@media (max-width: 480px) {
    .application-overview,
    .treatment-protocols,
    .monitoring-section,
    .side-effects-management,
    .special-situations,
    .practical-recommendations,
    .support-contacts {
        padding: 40px 0;
    }
    
    .overview-card,
    .protocol-content,
    .monitoring-card,
    .side-effect-card,
    .situation-card,
    .recommendation-section,
    .contact-card {
        padding: 1.5rem;
    }
    
    .hero-title {
        font-size: 1.8rem;
    }
    
    .hero-subtitle {
        font-size: 1rem;
    }
    
    .stat-number {
        font-size: 2rem;
    }
    
    .timeline-item,
    .management-step,
    .cytopenia-type,
    .cardiac-type,
    .gi-symptom,
    .pregnancy-details,
    .planning-phase,
    .modification-section,
    .reason-category,
    .flow-step,
    .criteria-checklist,
    .schedule-period,
    .tip-category,
    .doc-category,
    .consultation-group,
    .specialist-item {
        padding: 1rem;
    }
    
    .dose-card {
        padding: 1.5rem;
    }
    
    .dose-amount {
        font-size: 2rem;
    }
    
    .disclaimer-card {
        padding: 1.5rem;
    }
}

/* Анимации */
@keyframes fadeInUp {
    from {
        opacity: 0;
        transform: translateY(30px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

@keyframes slideInLeft {
    from {
        opacity: 0;
        transform: translateX(-30px);
    }
    to {
        opacity: 1;
        transform: translateX(0);
    }
}

.overview-card,
.monitoring-card,
.side-effect-card,
.situation-card,
.recommendation-section,
.contact-card {
    animation: fadeInUp 0.6s ease forwards;
}

.overview-card:nth-child(2) {
    animation-delay: 0.2s;
}

.overview-card:nth-child(3) {
    animation-delay: 0.4s;
}

.stat-item {
    animation: slideInLeft 0.6s ease forwards;
}

.stat-item:nth-child(2) {
    animation-delay: 0.2s;
}

.stat-item:nth-child(3) {
    animation-delay: 0.4s;
}

/* Печать */
@media print {
    .protocol-nav,
    .support-contacts,
    .medical-disclaimer {
        display: none;
    }
    
    .protocol-content {
        display: block !important;
        page-break-inside: avoid;
    }
    
    .application-hero {
        background: none !important;
        color: black !important;
        padding: 20px 0;
    }
    
    .overview-card,
    .monitoring-card,
    .side-effect-card,
    .situation-card {
        box-shadow: none;
        border: 1px solid #ddd;
        page-break-inside: avoid;
    }
}

/* Улучшение доступности */
.protocol-tab:focus,
.resource-link:focus {
    outline: 2px solid #3498db;
    outline-offset: 2px;
}

button {
    cursor: pointer;
}

/* Темная тема */
@media (prefers-color-scheme: dark) {
    .overview-card,
    .protocol-content,
    .monitoring-card,
    .side-effect-card,
    .situation-card,
    .recommendation-section,
    .contact-card {
        background: #2c3e50;
        color: #ecf0f1;
    }
    
    .overview-card h3,
    .monitoring-card h3,
    .situation-card h3,
    .recommendation-section h3,
    .contact-card h3 {
        color: #ecf0f1;
    }
}

/* Утилиты */
.bg-light {
    background-color: #f8f9fa;
}

.container {
    max-width: 1200px;
    margin: 0 auto;
    padding: 0 1rem;
}

/* Скрытие/показ протоколов */
.protocol-content:not(.active) {
    display: none;
}

/* Smooth transitions */
* {
    transition: color 0.3s ease, background-color 0.3s ease;
}

/* Улучшение читаемости */
p, li {
    line-height: 1.6;
}

/* Hover эффекты */
.goal-milestone:hover,
.response-card:hover,
.crisis-type:hover,
.phase-card:hover,
.transplant-card:hover,
.timeline-item:hover,
.management-step:hover,
.cytopenia-type:hover,
.cardiac-type:hover,
.gi-symptom:hover,
.planning-phase:hover,
.modification-section:hover,
.reason-category:hover,
.flow-step:hover,
.schedule-period:hover,
.tip-category:hover,
.doc-category:hover,
.consultation-group:hover,
.specialist-item:hover {
    transform: translateY(-2px);
    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.1);
}