/* Страница дозировок - стили */

/* Hero секция */
.dosage-hero {
    background: linear-gradient(135deg, #3498db 0%, #2980b9 100%);
    color: white;
    padding: 80px 0;
    text-align: center;
}

.hero-title {
    font-size: 2.5rem;
    font-weight: 700;
    margin-bottom: 1rem;
}

.hero-subtitle {
    font-size: 1.25rem;
    margin-bottom: 2rem;
    opacity: 0.9;
}

.dosage-highlight {
    display: flex;
    justify-content: center;
    gap: 2rem;
    flex-wrap: wrap;
    margin-top: 2rem;
}

.highlight-item {
    background: rgba(255, 255, 255, 0.15);
    backdrop-filter: blur(10px);
    padding: 1rem 2rem;
    border-radius: 20px;
    border: 1px solid rgba(255, 255, 255, 0.2);
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 0.5rem;
}

.highlight-label {
    font-size: 0.9rem;
    opacity: 0.9;
}

.highlight-value {
    font-size: 1.25rem;
    font-weight: 600;
}

/* Важное уведомление */
.important-notice {
    padding: 40px 0;
}

.notice-card {
    display: flex;
    align-items: flex-start;
    gap: 1.5rem;
    background: linear-gradient(135deg, #fff3cd, #ffeaa7);
    border: 2px solid #f39c12;
    border-radius: 15px;
    padding: 2rem;
    max-width: 1000px;
    margin: 0 auto;
}

.notice-icon {
    font-size: 2rem;
    min-width: 40px;
}

.notice-content h3 {
    color: #d68910;
    margin-bottom: 1rem;
    font-size: 1.5rem;
}

.notice-content p {
    color: #5d4e37;
    font-size: 1.1rem;
    line-height: 1.6;
    margin: 0;
}

/* Рекомендуемые дозировки */
.recommended-dosages {
    padding: 80px 0;
}

.recommended-dosages h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

/* Табы дозировок */
.dosage-tabs {
    display: flex;
    justify-content: center;
    gap: 1rem;
    margin-bottom: 3rem;
    flex-wrap: wrap;
}

.dosage-tab {
    background: #f8f9fa;
    border: none;
    padding: 1rem 2rem;
    border-radius: 25px;
    font-weight: 600;
    color: #555;
    cursor: pointer;
    transition: all 0.3s ease;
    font-size: 1rem;
}

.dosage-tab:hover {
    background: #e9ecef;
    color: #333;
}

.dosage-tab.active {
    background: linear-gradient(135deg, #3498db, #2980b9);
    color: white;
    box-shadow: 0 5px 15px rgba(52, 152, 219, 0.4);
}

/* Контент дозировок */
.dosage-content {
    display: none;
}

.dosage-content.active {
    display: block;
}

/* ХМЛ дозировки */
.dosage-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(350px, 1fr));
    gap: 2rem;
}

.dosage-card {
    background: white;
    border-radius: 15px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    overflow: hidden;
    transition: transform 0.3s ease;
}

.dosage-card:hover {
    transform: translateY(-5px);
}

.dosage-card.chronic-phase {
    border-top: 4px solid #27ae60;
}

.dosage-card.accelerated-phase {
    border-top: 4px solid #f39c12;
}

.dosage-card.blast-crisis {
    border-top: 4px solid #e74c3c;
}

.dosage-header {
    background: linear-gradient(135deg, #f8f9fa, #e9ecef);
    padding: 1.5rem;
    position: relative;
}

.dosage-header h3 {
    color: #2c3e50;
    margin-bottom: 0.5rem;
    font-size: 1.25rem;
}

.phase-badge {
    position: absolute;
    top: 1rem;
    right: 1rem;
    padding: 0.25rem 0.75rem;
    border-radius: 15px;
    font-size: 0.8rem;
    font-weight: 600;
}

.phase-badge.chronic {
    background: #27ae60;
    color: white;
}

.phase-badge.accelerated {
    background: #f39c12;
    color: white;
}

.phase-badge.blast {
    background: #e74c3c;
    color: white;
}

.phase-badge.all {
    background: #8e44ad;
    color: white;
}

.dosage-body {
    padding: 2rem;
}

.main-dose {
    text-align: center;
    margin-bottom: 2rem;
    padding: 1.5rem;
    background: linear-gradient(135deg, #f8f9fa, #e9ecef);
    border-radius: 10px;
}

.dose-amount {
    display: block;
    font-size: 2.5rem;
    font-weight: 700;
    color: #3498db;
    margin-bottom: 0.5rem;
}

.dose-frequency {
    font-size: 1.1rem;
    color: #555;
    font-weight: 500;
}

.alternative-dosing {
    background: #e8f4fd;
    padding: 1rem;
    border-radius: 8px;
    margin-bottom: 1.5rem;
    border-left: 4px solid #3498db;
}

.alternative-dosing p {
    margin: 0;
    color: #2c3e50;
    font-weight: 500;
}

.dosage-details,
.clinical-info,
.intensive-monitoring {
    margin-bottom: 1.5rem;
}

.dosage-details h4,
.clinical-info h4,
.intensive-monitoring h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.1rem;
}

.dosage-details ul,
.clinical-info ul,
.intensive-monitoring ul {
    list-style: none;
    padding: 0;
    margin: 0;
}

.dosage-details li,
.clinical-info li,
.intensive-monitoring li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
    border-bottom: 1px solid #f8f9fa;
}

.dosage-details li:last-child,
.clinical-info li:last-child,
.intensive-monitoring li:last-child {
    border-bottom: none;
}

.dosage-details li::before,
.clinical-info li::before,
.intensive-monitoring li::before {
    content: "→";
    color: #3498db;
    position: absolute;
    left: 0;
    font-weight: bold;
}

.warning-note {
    background: #fff3cd;
    border: 2px solid #f39c12;
    padding: 1rem;
    border-radius: 8px;
    margin-top: 1.5rem;
}

.warning-note p {
    margin: 0;
    color: #856404;
    font-size: 0.95rem;
}

/* ОЛЛ дозировки */
.all-dosage-info {
    max-width: 800px;
    margin: 0 auto;
}

.all-main-card {
    background: white;
    border-radius: 15px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    overflow: hidden;
    margin-bottom: 2rem;
    border-top: 4px solid #8e44ad;
}

.all-phases {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 1.5rem;
}

.phase-card {
    background: white;
    padding: 1.5rem;
    border-radius: 10px;
    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.1);
    border-left: 4px solid #8e44ad;
}

.phase-card h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.1rem;
}

.phase-details p {
    margin: 0.5rem 0;
    color: #555;
    font-size: 0.95rem;
}

.phase-details strong {
    color: #2c3e50;
}

/* Особые случаи */
.special-cases-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(350px, 1fr));
    gap: 2rem;
}

.special-case-card {
    background: white;
    border-radius: 15px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    padding: 2rem;
    border-left: 4px solid #9b59b6;
}

.special-case-card h3 {
    color: #2c3e50;
    margin-bottom: 1.5rem;
    font-size: 1.25rem;
}

.case-details {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.recommendation h4,
.precautions h4,
.monitoring-note h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.1rem;
}

.recommendation ul,
.precautions ul {
    list-style: none;
    padding: 0;
    margin: 0;
}

.recommendation li,
.precautions li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.recommendation li::before {
    content: "💊";
    position: absolute;
    left: 0;
}

.precautions li::before {
    content: "⚠️";
    position: absolute;
    left: 0;
}

.severity-levels {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.severity-item {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 1rem;
    background: #f8f9fa;
    border-radius: 8px;
}

.severity-grade {
    padding: 0.25rem 0.75rem;
    border-radius: 15px;
    font-size: 0.9rem;
    font-weight: 600;
    min-width: 80px;
    text-align: center;
}

.severity-grade.mild {
    background: #d4edda;
    color: #155724;
}

.severity-grade.moderate {
    background: #fff3cd;
    color: #856404;
}

.severity-grade.severe {
    background: #f8d7da;
    color: #721c24;
}

.dose-adjustment {
    font-weight: 500;
    color: #2c3e50;
}

.monitoring-note p {
    margin: 0;
    color: #555;
    font-style: italic;
}

.contraindication {
    background: #f8d7da;
    border: 2px solid #e74c3c;
    padding: 1.5rem;
    border-radius: 10px;
    text-align: center;
}

.contraindication h4 {
    color: #721c24;
    margin-bottom: 1rem;
}

.contraindication p {
    color: #721c24;
    font-weight: 500;
    margin: 0;
}

.recommendations h4 {
    color: #2c3e50;
    margin: 1.5rem 0 1rem 0;
}

/* Коррекция дозы */
.dose-modifications {
    padding: 80px 0;
}

.dose-modifications h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 1rem;
}

.section-intro {
    text-align: center;
    font-size: 1.1rem;
    color: #555;
    margin-bottom: 3rem;
    max-width: 800px;
    margin-left: auto;
    margin-right: auto;
}

.modifications-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(400px, 1fr));
    gap: 2rem;
}

.modification-card {
    background: white;
    border-radius: 15px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    overflow: hidden;
}

.modification-card.hematologic {
    border-top: 4px solid #e74c3c;
}

.modification-card.non-hematologic {
    border-top: 4px solid #f39c12;
}

.modification-card.drug-interactions {
    border-top: 4px solid #9b59b6;
}

.modification-header {
    background: linear-gradient(135deg, #f8f9fa, #e9ecef);
    padding: 1.5rem;
}

.modification-header h3 {
    color: #2c3e50;
    margin: 0;
    font-size: 1.25rem;
}

.modification-content {
    padding: 2rem;
}

.toxicity-table {
    overflow-x: auto;
    margin-bottom: 1.5rem;
}

.toxicity-table table {
    width: 100%;
    border-collapse: collapse;
    font-size: 0.9rem;
}

.toxicity-table th,
.toxicity-table td {
    padding: 0.75rem;
    text-align: left;
    border-bottom: 1px solid #eee;
}

.toxicity-table th {
    background: #f8f9fa;
    font-weight: 600;
    color: #2c3e50;
}

.toxicity-table tr:hover {
    background: #f8f9fa;
}

.monitoring-schedule h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.monitoring-schedule ul {
    list-style: none;
    padding: 0;
    margin: 0;
}

.monitoring-schedule li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.monitoring-schedule li::before {
    content: "📅";
    position: absolute;
    left: 0;
}

.toxicity-examples {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.toxicity-item h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.1rem;
}

.severity-actions {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.action-item {
    display: flex;
    gap: 1rem;
    padding: 0.75rem;
    background: #f8f9fa;
    border-radius: 8px;
    align-items: flex-start;
}

.severity {
    font-weight: 600;
    color: #e74c3c;
    min-width: 100px;
    font-size: 0.9rem;
}

.action {
    color: #555;
    font-size: 0.9rem;
    line-height: 1.4;
}

.interaction-scenarios {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.scenario h4 {
    color: #2c3e50;
    margin-bottom: 1rem;
}

.scenario-details p {
    margin: 0.5rem 0;
    color: #555;
    font-size: 0.95rem;
}

.scenario-details strong {
    color: #2c3e50;
}

/* Практические рекомендации */
.practical-recommendations {
    padding: 80px 0;
}

.practical-recommendations h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.recommendations-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 2rem;
}

.recommendation-card {
    background: white;
    padding: 2rem;
    border-radius: 15px;
    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.1);
    text-align: center;
    transition: transform 0.3s ease;
    border-left: 4px solid #3498db;
}

.recommendation-card:hover {
    transform: translateY(-5px);
}

.rec-icon {
    font-size: 2.5rem;
    margin-bottom: 1rem;
    color: #3498db;
}

.recommendation-card h3 {
    color: #2c3e50;
    margin-bottom: 1.5rem;
    font-size: 1.25rem;
}

.recommendation-card ul {
    list-style: none;
    padding: 0;
    margin: 0;
    text-align: left;
}

.recommendation-card li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
    border-bottom: 1px solid #f8f9fa;
}

.recommendation-card li:last-child {
    border-bottom: none;
}

.recommendation-card li::before {
    content: "✓";
    color: #27ae60;
    position: absolute;
    left: 0;
    font-weight: bold;
}

/* Калькулятор дозировки */
.dosage-calculator {
    padding: 80px 0;
}

.dosage-calculator h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 1rem;
}

.calc-intro {
    text-align: center;
    font-size: 1.1rem;
    color: #555;
    margin-bottom: 3rem;
    max-width: 800px;
    margin-left: auto;
    margin-right: auto;
}

.calculator-card {
    background: white;
    border-radius: 20px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    overflow: hidden;
    max-width: 1000px;
    margin: 0 auto;
}

.calculator-form {
    background: linear-gradient(135deg, #f8f9fa, #e9ecef);
    padding: 2rem;
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: 1.5rem;
}

.form-group {
    display: flex;
    flex-direction: column;
}

.form-group label {
    color: #2c3e50;
    font-weight: 600;
    margin-bottom: 0.5rem;
}

.form-group select {
    padding: 0.75rem;
    border: 2px solid #e9ecef;
    border-radius: 10px;
    font-size: 1rem;
    background: white;
    color: #2c3e50;
    transition: border-color 0.3s ease;
}

.form-group select:focus {
    outline: none;
    border-color: #3498db;
    box-shadow: 0 0 0 3px rgba(52, 152, 219, 0.1);
}

.calculator-results {
    padding: 2rem;
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.result-section h3 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.25rem;
}

.result-dose {
    font-size: 2rem;
    font-weight: 700;
    color: #3498db;
    text-align: center;
    padding: 1rem;
    background: linear-gradient(135deg, #f8f9fa, #e9ecef);
    border-radius: 10px;
}

.result-schedule,
.result-notes {
    font-size: 1.1rem;
    color: #555;
    padding: 1rem;
    background: #f8f9fa;
    border-radius: 8px;
    border-left: 4px solid #3498db;
}

.calculator-disclaimer {
    background: #fff3cd;
    border: 2px solid #f39c12;
    padding: 1.5rem;
    border-radius: 10px;
    margin-top: 1.5rem;
}

.calculator-disclaimer p {
    margin: 0;
    color: #856404;
    font-size: 0.95rem;
    line-height: 1.5;
}

/* Мониторинг эффективности */
.efficacy-monitoring {
    padding: 80px 0;
}

.efficacy-monitoring h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.monitoring-timeline {
    position: relative;
    max-width: 1000px;
    margin: 0 auto;
}

.monitoring-timeline::before {
    content: '';
    position: absolute;
    top: 0;
    left: 50%;
    width: 4px;
    height: 100%;
    background: linear-gradient(to bottom, #3498db, #2980b9);
    transform: translateX(-50%);
}

.timeline-item {
    display: flex;
    align-items: center;
    margin-bottom: 3rem;
    position: relative;
}

.timeline-item:nth-child(odd) {
    flex-direction: row;
}

.timeline-item:nth-child(even) {
    flex-direction: row-reverse;
}

.timeline-marker {
    width: 80px;
    height: 80px;
    background: linear-gradient(135deg, #3498db, #2980b9);
    color: white;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: 700;
    font-size: 1.25rem;
    position: relative;
    z-index: 2;
    flex-shrink: 0;
}

.timeline-content {
    background: white;
    border-radius: 15px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    padding: 2rem;
    margin: 0 2rem;
    flex: 1;
    max-width: 400px;
}

.timeline-content h4 {
    color: #2c3e50;
    margin-bottom: 1.5rem;
    font-size: 1.5rem;
}

.monitoring-details {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.lab-tests h5,
.clinical-goals h5 {
    color: #2c3e50;
    margin-bottom: 0.75rem;
    font-size: 1.1rem;
}

.lab-tests ul,
.clinical-goals ul {
    list-style: none;
    padding: 0;
    margin: 0;
}

.lab-tests li,
.clinical-goals li {
    padding: 0.25rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
    font-size: 0.95rem;
}

.lab-tests li::before {
    content: "🔬";
    position: absolute;
    left: 0;
}

.clinical-goals li::before {
    content: "🎯";
    position: absolute;
    left: 0;
}

/* FAQ дозировок */
.dosage-faq {
    padding: 80px 0;
}

.dosage-faq h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.faq-accordion {
    max-width: 800px;
    margin: 0 auto;
}

.faq-item {
    background: white;
    border-radius: 15px;
    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.1);
    margin-bottom: 1rem;
    overflow: hidden;
}

.faq-question {
    padding: 1.5rem 2rem;
    background: linear-gradient(135deg, #f8f9fa, #e9ecef);
    cursor: pointer;
    display: flex;
    justify-content: space-between;
    align-items: center;
    transition: all 0.3s ease;
}

.faq-question:hover {
    background: linear-gradient(135deg, #e9ecef, #dee2e6);
}

.faq-question.active {
    background: linear-gradient(135deg, #3498db, #2980b9);
    color: white;
}

.faq-question h4 {
    margin: 0;
    font-size: 1.1rem;
    font-weight: 600;
}

.faq-toggle {
    font-size: 1.5rem;
    font-weight: bold;
    transition: transform 0.3s ease;
}

.faq-question.active .faq-toggle {
    transform: rotate(45deg);
}

.faq-answer {
    display: none;
    padding: 2rem;
}

.faq-answer p {
    color: #555;
    line-height: 1.6;
    margin-bottom: 1rem;
}

.faq-answer ul {
    list-style: none;
    padding: 0;
    margin: 1rem 0;
}

.faq-answer li {
    padding: 0.5rem 0;
    color: #555;
    position: relative;
    padding-left: 1.5rem;
}

.faq-answer li::before {
    content: "•";
    color: #3498db;
    position: absolute;
    left: 0;
    font-weight: bold;
}

.faq-answer strong {
    color: #2c3e50;
}

/* Поддержка */
.dosage-support {
    padding: 80px 0;
}

.dosage-support h2 {
    text-align: center;
    font-size: 2.5rem;
    color: #2c3e50;
    margin-bottom: 3rem;
}

.support-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(400px, 1fr));
    gap: 2rem;
}

.support-card {
    background: white;
    padding: 2rem;
    border-radius: 15px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.1);
    border-left: 4px solid #3498db;
}

.support-card h3 {
    color: #2c3e50;
    margin-bottom: 1rem;
    font-size: 1.5rem;
}

.support-card p {
    color: #555;
    line-height: 1.6;
    margin-bottom: 1.5rem;
}

.contact-info {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.contact-item {
    display: flex;
    gap: 0.5rem;
    color: #555;
}

.contact-item strong {
    color: #2c3e50;
    min-width: 120px;
}

.resource-links {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.resource-link {
    color: #3498db;
    text-decoration: none;
    font-weight: 500;
    padding: 0.5rem 0;
    border-bottom: 1px solid #eee;
    transition: color 0.3s ease;
}

.resource-link:hover {
    color: #2980b9;
    text-decoration: underline;
}

/* Финальный дисклеймер */
.final-disclaimer {
    padding: 60px 0;
}

.disclaimer-card {
    background: linear-gradient(135deg, #fff3cd, #ffeaa7);
    border: 2px solid #f39c12;
    border-radius: 15px;
    padding: 2rem;
    max-width: 800px;
    margin: 0 auto;
}

.disclaimer-card h3 {
    color: #d68910;
    font-size: 1.5rem;
    margin-bottom: 1rem;
    text-align: center;
}

.disclaimer-content p {
    color: #5d4e37;
    font-size: 1.1rem;
    line-height: 1.6;
    margin-bottom: 1.5rem;
}

.disclaimer-content ul {
    list-style: none;
    padding: 0;
}

.disclaimer-content li {
    padding: 0.5rem 0;
    color: #5d4e37;
    position: relative;
    padding-left: 1.5rem;
}

.disclaimer-content li::before {
    content: "⚠️";
    position: absolute;
    left: 0;
}

/* Адаптивный дизайн */
@media (max-width: 1024px) {
    .monitoring-timeline::before {
        left: 30px;
    }
    
    .timeline-item {
        flex-direction: row !important;
    }
    
    .timeline-marker {
        margin-left: 30px;
        transform: translateX(-50%);
    }
    
    .timeline-content {
        margin-left: 4rem;
        margin-right: 0;
    }
}

@media (max-width: 768px) {
    .hero-title {
        font-size: 2rem;
    }
    
    .hero-subtitle {
        font-size: 1.1rem;
    }
    
    .dosage-highlight {
        flex-direction: column;
        align-items: center;
    }
    
    .highlight-item {
        width: 100%;
        max-width: 300px;
    }
    
    .notice-card {
        flex-direction: column;
        text-align: center;
    }
    
    .dosage-tabs {
        flex-direction: column;
        align-items: center;
    }
    
    .dosage-tab {
        width: 100%;
        max-width: 300px;
    }
    
    .dosage-grid,
    .modifications-grid,
    .recommendations-grid,
    .support-grid,
    .special-cases-grid {
        grid-template-columns: 1fr;
    }
    
    .all-phases {
        grid-template-columns: 1fr;
    }
    
    .calculator-form {
        grid-template-columns: 1fr;
    }
    
    .severity-item {
        flex-direction: column;
        gap: 0.5rem;
        text-align: center;
    }
    
    .action-item {
        flex-direction: column;
        gap: 0.5rem;
    }
    
    .recommended-dosages h2,
    .dose-modifications h2,
    .practical-recommendations h2,
    .dosage-calculator h2,
    .efficacy-monitoring h2,
    .dosage-faq h2,
    .dosage-support h2 {
        font-size: 2rem;
    }
}

@media (max-width: 480px) {
    .recommended-dosages,
    .dose-modifications,
    .practical-recommendations,
    .dosage-calculator,
    .efficacy-monitoring,
    .dosage-faq,
    .dosage-support {
        padding: 40px 0;
    }
    
    .final-disclaimer {
        padding: 40px 0;
    }
    
    .dosage-card,
    .modification-card,
    .recommendation-card,
    .special-case-card,
    .support-card {
        padding: 1.5rem;
    }
    
    .calculator-card {
        padding: 1.5rem;
    }
    
    .timeline-content {
        padding: 1.5rem;
    }
    
    .faq-question {
        padding: 1rem 1.5rem;
    }
    
    .faq-answer {
        padding: 1.5rem;
    }
    
    .dose-amount {
        font-size: 2rem;
    }
    
    .timeline-marker {
        width: 60px;
        height: 60px;
        font-size: 1rem;
    }
    
    .monitoring-timeline::before {
        left: 30px;
    }
}

/* Анимации */
@keyframes fadeInUp {
    from {
        opacity: 0;
        transform: translateY(30px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

.dosage-card,
.modification-card,
.recommendation-card,
.special-case-card,
.timeline-item,
.faq-item,
.support-card {
    animation: fadeInUp 0.6s ease forwards;
}

.dosage-card:nth-child(2) {
    animation-delay: 0.1s;
}

.dosage-card:nth-child(3) {
    animation-delay: 0.2s;
}

/* Утилиты */
.bg-light {
    background-color: #f8f9fa;
}

.container {
    max-width: 1200px;
    margin: 0 auto;
    padding: 0 1rem;
}